Plant Transcription Factor Database
Previous version: v3.0
Daucus carota
WOX Family
Species TF ID Description
DCAR_008812WOX family protein
DCAR_023274WOX family protein
DCAR_019432WOX family protein
DCAR_018901WOX family protein
DCAR_032388WOX family protein
DCAR_011793WOX family protein
DCAR_006582WOX family protein
DCAR_023593WOX family protein
DCAR_014309WOX family protein
DCAR_020646WOX family protein
DCAR_026401WOX family protein
DCAR_016960WOX family protein
DCAR_004032WOX family protein
DCAR_007980WOX family protein
DCAR_028033WOX family protein
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401

The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590